This workshop aims to take a closer look at how mathematical and computational models can help answer clinically relevant questions and enhance multimodal treatments. Currently, a wide range of modelling approaches study cancer and have a crucial role in treatment delivery from answering questions related to cancer biology and treatment efficacy to directly helping with treatment delivery. In this workshop, we would like to bring together clinicians, biomedical experts, experimentalists, and mathematicians to explore some of the relevant questions on multimodal treatment modelling, efficacy, optimization, drug resistance and clinical delivery.