Particle physics, astrophysics, and cosmology cover the study of the universe from its smallest to largest scales. We study them in order to understand both the fundamental interactions that govern the universe and its large-scale structure and history. Advanced detectors at collider facilities that accelerate particles to near the speed of light and telescopes that monitor the night's sky looking back to the time just after the Big Bang are used to collect vast amounts of data in complicated datasets. Analyzing these data requires modern tools, making use of advanced machine learning and high performance computing infrastructure. This workshop brings together physicists, statisticians, and machine learning experts in order to make the most use of this data and learn as much from it as possible by discussing how to address the complexities of these large and detailed datasets, searching for 1 in a trillion events, and understanding correlations between thousands of quantities.