The vaccine development pipeline is a time, cost and labour-intensive process. Mathematical and computational methods can alleviate challenges related to this intensive process as well as providing further insights into the efficacy and safety of vaccines. These methods are key components of model-informed vaccine development (MIVD) and quantitative systems pharmacology/toxicology (QSP/T). MIVD and QSP/T can be used in tandem to better understand the biological processes and outcomes from vaccination administration, spurring future research. This workshop will strengthen and contribute to the ongoing development of this interdisciplinary community of biologists, mathematicians and vaccinologists.