AILM2019 — Advanced Isotopic Labeling Methods for Integrated Structural Biology

The AILM workshop will focus on the development of isotopic labelling techniques and their application to the study of biomolecular structure and dynamics. Conference sessions covered developments in isotopic labelling strategies for NMR spectroscopy, mass spectrometry, neutron scattering and diffraction, as well as methodological approaches, such as co-expression, segmental labelling, specific labelling, labelling with paramagnetic tags, and sample production in vitro or in eukaryotic cells. The program also included elegant examples of the application of these methods to challenging systems such as high molecular weight proteins and nucleic acids complexes or direct studies of biomacromolecules in cells or tissues.