The Thirty-Third Annual Conference on Innovative Applications of Artificial Intelligence (IAAI-21) is a venue for papers describing highly innovative realizations of AI technology. The objective of the conference is to showcase successful applications and novel uses of AI. The conference will use technical papers, best practice papers, invited talks, and panel discussions to explore issues, methods, and lessons learned in the development and deployment of AI applications; and to promote an interchange of ideas between basic and applied AI and the discourse on the actual deployment of AI in practice.