The development, organization and role of mucociliary interactions are imperative for the maintenance of health and function of the epithelial tissues in which they are present. For proper performance the accurate and coordinated succession of underlying mechanisms is essential. Environmental, pathogenic or genetic factors can induce changes in cilia or mucus function as well as alter mucociliary interactions, which can have a negative impact on correct cellular and tissue function and thus can lead to a diverse group of diseases and syndromic disorders. This Gordon Research Seminar (GRS) aims to facilitate the exploration of these complex processes among trainee and early career scientists, and to promote open discussion of current breaking scientific findings and establish a basis for future directions in the field.