Developing multi-dimensional electron microscopy would have transformative impact in physics, chemistry, materials science, nanoscience and other fields. Advancing the field requires integration of state-of-the-art atomic electron tomography, ptychography, 4D scanning transmission electron microscopy and spectroscopic techniques as well as powerful computational algorithms and mathematical modeling. This workshop will provide the opportunity to present and exchange ideas, share data, and introduce new tools and develop new imaging paradigms needed in a variety of fields.