With the substantial recent progress in connectomics, the study of comprehensive maps of nervous systems, much more is known about the connectivity structure of brains. This has led to a multitude of new questions about the relationship between connectivity patterns, neural dynamics and brain function, many of which lead to new mathematical problems in graph theory and dynamics on graphs. The goal of this workshop is to bring together a broad range of researchers from neuroscience, physics, mathematics, and computer science to discuss new challenges in this emergent field and promote new collaborations.