This conference will bring together scientists and students working on the co- and post-translational regulation of proteins, terminal protein modifications and modifying enzymes, and the impact of such terminal modifications at the protein level as well as in a broader biological perspective including human disease and plant homeostasis. The event will be relevant for researchers in the fields of structural biology, biochemistry, molecular biology, cell biology, systems biology and biomedicine, and encompass model systems and biological regulation in bacteria, yeast, mammals and plants.