This EMBO-FEBS Lecture Course will bring together leaders in the fields of interorgan crosstalk between the nervous system, immune system, kidney, lung, heart, gut, liver, fat, bone, blood and bone marrow. We will also consider effects of the microbiome, metabolome and host pathogen interactions. One unifying theme of the course will be immune responses to injury/infection, locally and systemically (remote injury). The EMBO-FEBS Lecture Course represents a unique opportunity for investigators to participate in cross-disciplinary, multi-organ discussions in order to gain new insights into their research.