EMBO Workshop — Neural stem cells: From basic understanding to translational applications

The mammalian brain is developed during embryogenesis when differentiated cells form complex networks, while it is colonized by new cells throughout adulthood which reform existing connectivity. Discovery of key steps of brain development under the prism of evolution and design of novel cellular therapies are central goals for the coming decades. Thus, neural stem cell based (NSCs) therapies are highly promising new strategies against neurodevelopmental, traumatic, and neurodegenerative diseases. Understanding of how aspects of NSC basic biology has potentiated the advancement of clinical applications on drug discovery and cell replacement therapies will be discussed. Emphasis will be given to model systems mimicking human physiology and pathophysiology, an essential step bridging knowledge of basic and clinical research. In the workshop world leading experts, young investigators and future scientists studying basic and translational aspects of NSCs biology will discuss present knowledge and future perspectives on cellular therapies.