The first GRC on the topic of biomaterials was held in 1966. Over the past five decades, the field has grown substantially, both in numbers and in scope, leading to a vibrant, multidisciplinary community of researchers who share interests in developing materials for a wide range of medical applications. Building on this rich history, the 2023 GRC and GRS on Biomaterials and Tissue Engineering will focus on the design, function, and translation of bio-instructive materials, with a particular emphasis on material modulation of biological activity.