The meeting in Mainz will focus on “advanced endocrine malignancies”. Especially in advanced oncologic cases, we are faced with many uncertainties; the opinions about indications for and limits of surgery are very diverse. As usual, ESES working groups will prepare profound statements based on in-depth literature reviews and research data for malignancies of thyroid, adrenals, and the gastroenteropancreatic neuroendocrine system. Of course, original research results will also be presented at the meeting.