The IEEE International Conference on Autonomic Computing and Self-Organizing Systems (ACSOS) is the leading forum to share the latest research results, ideas and experiences in autonomic computing, self-adaptation and self-organization. Now in its 5th edition, ACSOS was founded in 2020 as a merger of the IEEE International Conference on Autonomic Computing (ICAC) and the IEEE International Conference on Self-Adaptive and Self-Organizing Systems (SASO).