For electrons moving in chiral molecules, one spin projection is more likely to be transported through the structure than the other, despite that the chiral molecule is often diamagnetic. This is the chiral induced spin selectivity (CISS) effect. It is a quantum phenomenon that is based on chirality, spin-orbit coupling, particle-particle interaction, and compositeness. However, exactly how these aspects are brought together and result in the CISS effect is yet an enigma. This question, among several others, will be discussed in this seminar, with the aim to reach some clarification.