EES25-05 — EMBO | EMBL Symposium The ageing genome: from mechanisms to disease

Ageing is often considered a complex phenotype that affects multiple organs and tissues in a time-dependent manner. This may result in the aged population consuming a myriad of medications, each aimed to treat, but not cure, the affected tissue. Recent studies have demonstrated that the “Primary Hallmarks of Ageing” are a set of five molecular mechanisms that malfunction, independent of tissue type, and drive ageing. Hence, focusing on these five hallmarks simplifies the efforts to understand ageing-associated disease. This, the second edition of this symposium will bring together an all-new, international line-up of speakers to continue the exchange on the basic/mechanistic aspects of chromosome biology with the applied and emerging field of ageing sciences. As more and more interventions and supplements flood the market, claiming to attenuate aging processes, it is critical that we investigate genomic changes during the ageing process. To keep the symposium fresh, in 2025 there will be new emphasis on the importance of chromatin changes and telomere dysfunction, nonetheless keeping in mind how they also affect DNA damage and repair responses

This symposium will bring together many diverse fields across topics including the below, and tie them together with the field of ageing biology and its relevant models of ageing.

Topics: Cell Biology and Biophysics