With increased complexity of systems, we believe that integrating data-driven and model-driven methods on the one hand and hybrid solution methods combining simulative with analytic-numeric solutions on the other hand will become necessary. While isolated attempts at such an integration do exist, this Dagstuhl Seminar will bring intense focus on issues arising in interfacing data-driven and model-driven methods on the one hand and simulative and analytic-numeric solution on the other hand. This will be done while keeping in mind real-world applications and software packages to sup-port such integration.