The annual international conference on Intelligent Systems for Molecular Biology (ISMB) is the flagship meeting of the International Society for Computational Biology (ISCB). The 2020 conference is the 28th ISMB conference, which has grown to become the world's largest bioinformatics/computational biology conference. ISMB brings together scientists from computer science, molecular biology, mathematics, statistics and related fields and provides an intense multidisciplinary forum for disseminating the latest developments in bioinformatics/computational biology.