The 27th international conference on Information Processing in Medical Imaging (IPMI) will be held in Rønne at the island of Bornholm in Denmark from Sunday June 27th to Friday July 2nd, 2021. The IPMI conference series focuses on novel developments in the acquisition, formation, analysis and display of medical images. IPMI places the highest importance on high-quality submissions coupled with presentations and thorough discussions of the presented contributions. IPMI 2021 will continue the scientific focus and traditions established in 26 prior conferences over the last 50 years.