The 12th Course of the International School of Radiation Damage and Protection will be held at "Ettore Majorana Foundation and Centre for Scientific Culture" in Erice (Sicily), Italy, from the 9th April until the 16th April 2022. The objective of this course is to update the knowledge of both professionals and newcomers in the field of radiation damage and activation of accelerator components. It gives a summary of fundamental quantities and concepts and provides an overview on computational and experimental methods for the assessment of radiation damage of materials and electronics, as well as activation properties of construction materials. The course puts also emphasis on applications and lessons learned at high-energy accelerators, experiments and high power target facilities. Moreover, it addresses synergies with other areas such as light sources and space radiation applications.