The goal of this meeting is to bring together theoreticians, modelers, and observers to discuss the computational astrophysics and observational challenges for the next generation of observatories, focusing on the next generation Very Large Array (ngVLA). The formation of planetary systems, the evolution of galaxies, and the observation of electromagnetic counterparts of gravitational wave events will be fertile grounds for discovery in the next decades and are core science goals for the ngVLA. The challenge to simulators is to develop predictive models that can be accurately compared against observations, while observers need to generate measurements that can effectively constrain the models.