This EMBO workshop will explore Ub/Ubl networks in different organisms, focusing on the similarities and differences in fundamental properties, to elucidate the wiring of Ub/Ubl networks in health and disease. The primary goals of this meeting will be: i) present an overview of current knowledge with the latest research discoveries and cutting-edge approaches; ii) foster the development of trainees and junior scientists; iii) promote collaborations among leading scientists from diverse backgrounds and newcomers in the field; and iv) accelerate translational research.