In the last years, there is a great concern about the problem of bacterial resistance to antibiotics used in human medicine as well as in veterinary. The use of antibiotics constitutes an important factor for the selection of resistance, not only among pathogenic bacteria but also among the commensal ones. Antimicrobial resistance is a major problem in public health due to the possibility of therapeutic failure. The appearance of multiresistant bacteria is probably accompanied by co-contamination of the environment, leading to a major clinical and public health concern within the lifetime of most people living today. The extensive use has heightened concerns about the expression of antimicrobial resistance, which impacts human and animal safety, food safety and environmental exposure. Antibiotic resistance is an emergent problem, and for this reason, the WHO appealed for an urgent and concerted action by governments, health professionals, industry, civil society and patients to slow down the spread of drug resistance, limit its impact today and preserve medical advances for future generations. In the latest years, much investigation was developed to understand the emergence of the resistance genes and their spread but this fact does not let us control totally this problem. In this conference, an attempt has been made to present the latest research on possibilities to manage this question.