BBSRC DTP-CASE PhD studentship (SCI2007)

Title: Evolution of Yeast Variation During Continuous Manufacturing Processes

Evolution of yeast diversity during biomanufacturing processes This project explores the heterogeneity of yeast cell populations used to produce high-value proteins (e.g. vaccines, therapeutics). While the annual market for these yeast-derived products is over $40Bn, the production cell populations become heterogeneous, developing mixed phenotypes and lowered production yields. Such yeast diversification presents intriguing academic questions and industrial application opportunities. The project will investigate key yeast products (e.g. VLP vaccines, albumin) in testing two main hypotheses: (i) high-yield production drives diversification and selection in yeast cultures; (ii) natural yeast diversity is exploitable to address this problem. Training will be given in state-of-the-art technologies including time-lapse microscopy, image streaming flow cytometry, genome-/single cell-sequencing, microfluidics, fermentation scale-up. The student will be based in the University's vibrant and well supported fungal-biology grouping. An industry placement with Phenotypeca Ltd will include broader commercial training. The cross-sector supervisory team combines extensive project-relevant expertise, ensuring a high-quality programme.

Entry Requirement: Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in a science degree. For example: Biochemistry; Chemistry; Physics; Pharmacy or Food Science.

Studentship information: It is fully funded for four years and includes fees (£4500 p.a.) plus an annual stipend (£15,609 p.a.), set by the Research Councils.

How to apply:

The preferred start date is 01/10/2021. The 4-year PhD studentship will be filled as soon as a suitable candidate is found. Candidates are encouraged to apply via https://www.nottingham.ac.uk/bbdtp/apply/apply-online.aspx as soon as possible. 

Prospective applicants are encouraged to contact simon.avery@nottingham.ac.uk for more details about the project, or you can visit https://www.nottingham.ac.uk/bbdtp/case-2020/case-2020.aspx

Closing Date: noon 4th May 2021 UK time.

Eligibility: This studentship is available to UK students and International (EU are now classified as international students. EU national have lived in the UK for 3 years prior to the start of their studies with pre settlement may be considered as Home(UK) candidates.

Closing Date: 04 May 2021
Category: Studentships