Originally introduced by Martin Bartels in the early nineteenth century, and then extensively developed by Élie Cartan in the first half of the twentieth century, the method of moving frames is a powerful tool for studying the geometry of curves, surfaces, and, more generally, submanifolds under the action of a group of transformations. In 1999, a new and more general formulation of moving frame was introduced by Fels and Olver which led to a dramatic resurgence of interest in the method accompanied by a striking extension of the range of applications. The workshop will bring together a diverse group of experts with the goal of exploring existing and emerging applications of the moving frame method to differential equations and integrable systems in physics, to computer vision and object recognition, medical imaging, broken object reconstruction, discrete and differential-difference equations, geometric numerical integration, and much more.