The International Conference on Practice and Theory of Public-Key Cryptography (PKC) is the main annual conference covering all aspects of public-key cryptography. PKC 2022 is sponsored by the International Association for Cryptologic Research (IACR) and will take place in Yokohama, Japan on March 7-11 2022, assuming the global situation regarding COVID-19 permits this. It has almost been a quarter century since the conference was initiated 1998, and PKC 2022 is the 25th edition of the PKC conference.