This EACR Conference, the second on the topic following a sold-out 2019 edition, will provide a comprehensive overview of liquid biopsies in cancer. It will cover what is already in clinical practice, what is on the horizon for liquid biopsies in cancer patient management and the latest new techniques for high sensitivity profiling of solid tumors in the blood. This meeting aims to develop our understanding of the potential of liquid biopsies. This includes to support early detection of cancer; as prognostic, pharmacodynamic and predictive biomarkers of treatment efficacy and resistance; and for patient monitoring, including of minimal residual disease for early identification of disease relapse. It will also explore how liquid biopsies can be incorporated in cancer patient management and how implementation of liquid biopsies can change clinical practice.