The overall goal of this EMBO Workshop is to provide the most important and up-to-date research in the field of metabolism. The workshop will focus on understanding the recent progress in adipocyte biology (cell fate and browning), liver metabolism and its crosstalk with microbiota as well as how all these alteration in metabolism might affect heart disease. Special interest will take the importance of the organ crosstalk and how the signalling in one tissue could affect the metabolism in other tissue. The goals of this EMBO Workshop are to provide important new insights into the primary pathogenesis of these disorders and especially focus on those that might lead to new therapies.