This workshop will bring together researchers from biophysics/mechanobiology experiment, soft active matter theory and non-equilibrium statistical mechanics. There will be a mixture of pedagogical overview talks and research talks. The meeting aims to bring together mathematicians and statistical physicists specializing in the fundamental properties of fluctuations and response in nonequilibrium states with theoretical researchers in soft matter working on active matter and biological physics and experimental researchers in biology and biophysics. We expect to enable new collaborations and cross-fertilization of ideas. In short, we expect that understanding the living world will provide challenges that will stimulate new fundamental thinking in statistical physics while current research in this field will help to structure our ever-expanding knowledge of living matter as a nonequilibrium dynamical system.