ICoMS 2023 is organized to bring together worldwide leading researchers and practitioners interested in advancing the state of the art in Mathematics and Statistics, for exchanging knowledge that encompasses a broad range of disciplines among various distinct communities. It is hoped that researchers and practitioners will bring new prospects for collaboration across disciplines and gain inspiration to facilitate novel breakthroughs. The themes for this conference are thus focused on "Mathematics of Digital Twins - Analysis, Stochastics and Numerics".