ESCAPE-33 anticipates emerging and significant challenges in Process Systems Engineering as these relate to the sustainable development of chemical processes, the development and the systematic evaluation of processing technologies and process innovations, and research promoting circular economy paradigms including social aspects and social engagement networks to incentivize and involve citizens. ESCAPE 33 recognizes particular importance to industrial biotechnology as a driver and enabler for new chemistries, alongside data engineering as a technological challenge with an apparent impact on many systems technologies.