Applications are invited for a Research Associate/Fellow position to work on a BBSRC funded project investigating cell fate regulation during gastrulation in the laboratory of Dr. Ramiro Alberio (U. of Nottingham), in collaboration with Prof. Jennifer Nichols (U. of Cambridge) and Dr Matt Loose (U. of Nottingham).
The project will investigate the molecular mechanisms that regulate the onset of gastrulation in mammals. The investigations will include working with embryos and embryonic stem cells and using next generation sequencing as a mean to understand cellular differentiation in early embryos. This position will especially suit candidates with experience in single cell RNA seq., embryology and micromanipulation. The successful candidate will use in vitro functional assays to model developmental trajectories using human embryonic stem cell (hESC), as well as gene editing of pig zygotes to create embryonic mutants. All the technologies required for the project are currently performed in our laboratory. This post offers a unique opportunity to work in fast developing fields (stem cell biology, single cell genomics and gene editing) and to develop skills in state-of-the-art technologies.
Applicants must be highly motivated and self-driven, with a PhD (or near completion) in cell/developmental or related biological science. The selected individual will have experience in some of the following areas: stem cell biology (preferably hESC), single cell RNA seq, gene editing, and bioinformatics. A track record of publishing research and excellent presentation skills are also desirable. Experience in embryo dissection, generation of transgenic reporter cell lines, gene targeting and other genome editing techniques are also relevant for the project.
The post is available from 1 January 2019 or as soon as possible thereafter and will be offered on a fixed-term contract until 31 December 2021. This is a full-time post, however job share may be considered.
The applicant will be based at the University of Nottingham, but willingness to travel within the UK to work with collaborators in Cambridge, is desirable.
For more information on our lab activities please visit: http://www.nottingham.ac.uk/Biosciences/People/ramiro.alberio
For informal enquiries please contact Ramiro Alberio (Ramiro.alberio@nottingham.ac.uk) Please note that applications sent directly to this email address will not be accepted.
Closing Date: 02 Nov 2018
Category: Research and Teaching (R&T)
