Technician (Fixed term) (MED148020)

This project is funded through a NovoNordisk drug development grant, in collaboration with colleagues from the University of Southern Denmark in Odense, Denmark but will be based at the University of Nottingham in the Division of Cancer and Stem Cell Sciences. The host laboratory, Tumour and Vascular Biology laboratories, specialise in the vascular biology of tumours, and other systems, including the renal cortex.

The post will investigate the therapeutic potential of target a newly identified pathway that is relevant in diabetic kidney disease progression.  Diabetes is the leading cause of renal failure in the Western world and is caused by damage to the glomerular and tubular tissues induced by hyperglycaemia.  Evidence suggests that targeting extracellular matrix components to reduce inflammation and blood vessel growth is a promising avenue to generate new treatments.

 The research will be composed of in vivo support and in vitro assays. Applicants must have experience in in vivo and ex vivo assays, particularly in terms of dealing with kidney disorders, collection of urine from mice, isolation of fresh tissue for experiments, and demonstrated ability to independently run in vivo experiments, including imaging of specific lesions in experimental animals. Expertise in using advanced imaging facilities (e.g. fluorescence, OCT, infrared imaging, etc) in live animals is essential. We would also look for someone with cell biological, immunofluorescence and staining techniques.   These include, cell culture, protein and RNA assays, histology and confocal usage. Additionally, experience working with rodents and tissue handling would be required. A Home Office personal license is required.

This role is available on an 11-month fixed-term basis. Hours of work are full-time (36.25 hours); however, applications are also welcome from candidates wishing to work part-time (minimum 29 hours per week). Please specify in your application if you wish to work part time and the number of preferred hours. Job share arrangements may be considered.

Informal enquiries may be addressed to Beverley Bramley or email Beverly.Bramley@nottingham.ac.uk. Please note that applications sent directly to this email address will not be accepted.

Closing Date: 01 Jul 2020
Category: Technical (TS)