Research Fellow in Immunology and Inflammation (MHLRM1245)

Are you an ambitious researcher looking for your next challenge?  Do you have a background in immunology and macrophage/monocyte biology.  Do you want to further your career in one of the UK’s leading research intensive Universities?

 This post is funded from MRC project grant awarded to Professor Savic. The aim of the project is to investigate the pathogenesis of recently discovered haematoinflammatory disorder called VEXAS syndrome. By studying this condition, the group aims to better understand the link between the bone marrow dysfunction caused by post-zygotic, somatic mutations and age-related, inflammation or inflammageing. The work on this project will be conducted in close collaboration with Professor David Kent, based at the York University, and Dr James Poulter, based at the University of Leeds, who are co-applicants on the grant.  The post holder will be working closely with a research technician, and two PhD students to deliver objectives of this project. There will be regular meetings with Professor Kents' research group to ensure that project aims are delivered in a timely fashion. The post holder will be expected to develop functional assays to validate effects of novel genetic findings on inflammatory function of myeloid cells. Previous experience in immunology, use of techniques such as of fluorescent activated cell sorting (FACS), for cell separation, multiplex-based assays for cytokine evaluation, tissue culture and CRISPR-Cas9 genome editing or lentiviral plasmid transduction to manipulate and study immunometabolism of myeloid cell lines is desirable. 

This role will be based at St James’s University campus. 

Professor Sinisa Savic, Associate Professor 

Email: s.savic@leeds.ac.uk 

Closing Date: 26 Mar 2024

Section: Research

Salary: £37,099 to £44,263 per annum