PhD Studentship â A proteomic approach to deciphering the immunological outcomes of respiratory and skin sensitisation. (1043618BJ)

PhD Supervisor: Dr Paul Skipp                              

Co-supervisor: Prof Tim Elliott, Prof Ratko Djukanovic, Dr Ben Nicholas, Dr Maja Aleksic, Dr Stella Cochrane

Application Deadline: 15th September 2018

Interviews will be held from 1st August 2018 onwards

PhD Description:

Allergies to small organic chemicals are a public health concern and can manifest themselves in a variety of clinical outcomes. For example, allergic contact dermatitis (ACD) is a T-cell mediated, delayed hypersensitivity that typically results in skin symptoms, which can be severe but not life-threatening. By contrast, chemical respiratory and drug allergies can be IgE-mediated and potentially fatal. What drives the subsequent divergent immunological outcomes i.e. the differences in the main effector responses associated with skin and respiratory sensitisation is unknown. 

In collaboration with Unilever PLC, this research project capitalises on novel proteomic techniques recently developed at the UoS to characterise both the proteins modified and the MHC peptide antigens presented after sensitiser exposure. This programme of research presents an exciting opportunity to investigate and elucidate the differences in effector responses between skin and respiratory sensitisation at the molecular level. Working within a research team based within the Centre for Proteomic Research, the successful student will develop expertise in using the latest techniques in proteomics, immunopeptidome analysis and bioinformatics.

The project is funded for 3 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in Biological Sciences or allied subjects. Funding will cover fees and an enhanced stipend of £ 17,777 per annum for 2018/19. 

Due to funding restrictions this position is only open to UK/EU applicants

Applications for an MPhil/PhD in Biological Sciences should be submitted online at:

https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Login?pos=4973&majr=4973&term=201819  Please place Dr Paul Skipp name in the field for proposed supervisor.

General enquiries should be made to Dr Paul Skipp at 

pjss@soton.ac.uk.  Any queries on the application process should be made to pgafnes@soton.ac.uk

Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified

The University of Southampton and Biological Sciences both hold an Athena Swan Silver Award, respectively, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine.  Due consideration will be given to applicants who have taken a career break.  University benefits include onsite childcare facilities, state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.

Closing Date: 15 Sep 2018
Post Type: PhD Studentship (Funded)