Research Fellow in Synthetic Organic Chemistry/Chemical Biology (1131719EB)

Applications are invited for a highly motivated Research Fellow in Synthetic Organic Chemistry/Chemical Biology to work under the supervision of Dr Sam Thompson on a research project funded by the EPSRC for a period of 24 months in the first instance. The project will develop a toolkit of covalent chemical probes for the inhibition of therapeutically–relevant protein–protein interactions (PPIs) that are critical in myriad diseases. These agents will consist of conformationally–preorganised peptidomimetic scaffolds armed with electrophilic warheads. The scaffolds may be functionalised to provide complementary contacts for a given protein surface and to form a covalent bond between the mimetic and nucleophilic amino acid side–chains displayed on the surface of the target protein.

Extensive experience in multi-step Synthetic Organic Chemistry and characterisation of complex organic molecules is essential, and the successful candidate should hold a PhD in this discipline or a closely related area (or near completion prior to taking up the appointment). An excellent work ethic, commitment to achieve the project aims and ability to work as part as a collaborative team will be essential. You will also play a key role in the general running of the laboratory, including supervision of undergraduate and postgraduate project students as required. The following are desirable but not essential: (i) experience of NMR techniques and single-crystal x-ray crystallography for elucidating solution- and solid-state conformation and probing non-covalent interactions, (ii) experience with the synthesis and characterisation of organoboron compounds, (iii) experience of handling protein samples and running biophysical assays, along with interpretation and presentation of the resultant data. The development of written/oral communication skills will be actively encouraged through funding to present at meetings and conferences.

The group is based in the modern synthetic chemistry laboratories in the School of Chemistry on the Highfield Campus, which benefits from first class support for synthetic chemistry, with exceptional MS, NMR and x-ray facilities, each supported by dedicated specialist staff. This position is available from 1 July 2019, or as soon as possible thereafter. 

Informal enquiries should be made to Dr Sam Thompson, School of Chemistry, University of Southampton on st3a15@soton.ac.uk or  

+44 (0) 23 8059 2187 [Internal 22187]

At the University of Southampton, we value diversity and equality.  The University recognises that employees may wish to have working patterns that fit with their caring responsibilities or work-life balance.Due consideration will also be given to applicants who have had career breaks for reasons including maternity, paternity or adoption leave, disability or illness.  Both the University of Southampton and Chemistry are proud to hold Athena Swan Silver Awards.

Applications for Research Fellow positions will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification.  The title of Research Fellow will be applied upon successful completion of the PhD.  Prior to the qualification being awarded the title of Senior Research Assistant will be given.

Application procedure:

You should submit your completed online application form at https://jobs.soton.ac.uk.The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Elsa Samwell (Recruitment Team) on +44 (0) 23 8059 2507.  Please quote reference 1131719EB on all correspondence.

Closing Date: 05 May 2019
Post Type: Education, Research & Enterprise