The need to understand basic epidemiological concepts cannot be overstated for researchers wanting to make a career in any medical field, including hepatology. This course will give an overview of common and cutting-edge methodologies in clinical epidemiology that will be highly useful for clinicians wanting to develop their capacity to read, interpret, and understand limitations of clinical studies in medical journals. Instead of presenting a clinical case, the course will focus on practical skills needed to understand or design clinical studies and to be able to spot flaws and limitations in their own and other’s research work. In essence, this course will improve the knowledge of applied clinical study design and methodology for the next generation of clinicians and clinical researchers in hepatology.