This workshop explores recent advances in the use of flexible machine learning techniques alongside semiparametric and nonparametric statistical methods in causal inference. Recent methodological work has focused on combining modern machine learning tools with the inferential rigor of semiparametric and nonparametric frameworks to estimate causal parameters in complex, high-dimensional settings. The aim is to move beyond the predictive focus typical of standard machine learning, and instead develop estimators that enable valid causal inference while achieving desirable statistical properties such as efficiency and robustness. The workshop will highlight cutting-edge developments and foster discussion on future directions in this rapidly evolving area.