Keystone Symposia: 3D Genome - Gene Regulation and Disease

Transcription of the eukaryotic genome is not only driven by the cis regulatory elements embedded in the linear DNA sequence but also by the way chromosomes fold in the three-dimensional (3D) nuclear space. Growing evidence has pointed to a key role of the 3D genome architecture in gene regulation and human disease; however, the details of dynamic chromatin organization in different cell types remain opaque. Additionally, how chromatin organization shapes the gene regulatory program and influence disease pathogenesis has not been fully elucidated. The major objective of this conference is to accelerate the study of 3D genome organization; particularly with regard to gene regulation and human disease.

Topics: molecular biology, genetics, genomics, 3D genome architecture, epigenomics, computational biology