Computational Microscopy

The goal of this long program proposal is to bring together senior and junior applied mathematicians, physicists, chemists, materials scientists, engineers and biologists to discuss and debate on the current status and future perspectives of modern microscopy using computation, mathematics and modeling. Cryo-EM has revolutionized biology and life science (including very recently solving the 3D atomic structure of COVID-19, which has been greatly facilitating the development of the vaccines) and aberration-corrected electron optics and high brightness X-ray sources have transformed physical science imaging. The next steps in these fields will advance by orders of magnitude the temporal resolution and energy resolution, while maintaining atomic spatial resolution, in a variety of sample environments from near zero Kelvin in vacuum to temperatures of a thousand degrees in a highly corrosive atmosphere. These advances will transform research in macromolecules, materials, energy technologie