This EMBO Workshop on inter-organelle contacts biology, now at its 3rd edition, aims at bringing together the community of scientists in this field to share their work, experience, expertise, and vision. It also aims to promote collaborations, to update the nomenclature, and to foster initiatives that, ultimately, will help scientists in biomedical research to capitalize on the opportunities offered by this new field of cell biology. To that end, this year’s edition features an extended program and a large number of long- and short-talks to be selected from submitted abstracts.