After the editions of 2014 in Burgos, 2016 in Gargnano and 2018 in Madrid, the 4th edition of the E3 Mediterranean Symposium: Electrochemistry for Environment and Energy (E3MS) returns in Italy at Orvieto as a joint event with GEI2022. The two intertwined meetings share the interest for the themes of the electrochemical devices for energy conversion, production and storage (lithium-, sodium- batteries, fuel cells etc.), the use of electrochemical sensors and development of special electrochemical methods/electrodes for environmental analysis as well as all the aspects relevant to industrial electrochemistry: sustainable production processes, utilization of electrochemical methods for disposal/recycling/remediation, circularity of productive electrochemical processes and electrochemical decarbonisation. These outlines of the 4th E3MS reveal the centrality of Electrochemistry as a science of the future for the realization of a sustainable, smart and green development.